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Posts Tagged ‘AIDS’

Cure For HIV Imminent?

Ben Cohen · May 03,2013
HIV cells (image via Shutterstock)

HIV cells (image via Shutterstock)

The Telegraph broke this last week, raising hope for millions around the world diagnosed with HIV:

Danish scientists are hoping for results that will show that “finding a mass-distributable and affordable cure to HIV is possible”.

They are conducting a clinical trial to test a “novel strategy” in which the HIV virus is “reactivated” from its hiding place within human DNA and potentially destroyed permanently by the immune system.

The move would represent a step forward in the attempt to find a cure for the virus, which causes Aids.

The scientists are currently conducting human trials on their treatment, in the hope of proving that it is effective. It has already been found to work in laboratory tests.

The technique involves unmasking the “reservoirs” formed by the HIV virus inside resting immune cells, bringing it to the surface of the cells. Once it comes to the surface, the body’s natural immune system may be able to kill the virus.

However, the Huffington Post released this story yesterday, warning everyone not to gett too excited:

An HIV cure “within months?” Not exactly.

Researchers from Denmark have begun human clinical trials in their experimental HIV treatment, The Telegraph first reported. However, the team is not on the“brink” of a cure for HIV, as some have said; they instead expect the first results from the trial “within months.”

“We’re not months away from a cure,” Kevin Robert Frost, CEO of amfAR, the Foundation for AIDS Research, told The Huffington Post. “There is still a lot of work that has to be done.”

Funded by amfAR, Danish researchers recently launched the initial stage of their clinical trial following an in vitro laboratory study conducted at Aarhus University Hospital. In the study, the researchers found success in using a specific drug to reactivate the hidden form of HIV. Only then, once the virus is drawn out of the “reservoirs” it forms in immune cells, can researchers even attempt to neutralize the HIV infection.

“Essentially, the biggest obstacle to a cure for people with HIV is that the virus lives in viral reservoirs which are not susceptible to the current drugs we have,” Frost explained. “What a lot of scientists have been trying to do lately is figure out if there are drugs that can stimulate the viral reservoirs so that we may begin to target them.”

Either way, it definitely looks like some major headway is being made in the fight against the deadly disease.

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An ‘Almost’ Cure: Baby Treated for HIV Shows No Signs of Infection

March 04,2013
baby_hiv_cure_280

baby_hiv_cure

The Daily Banter Headline Grab from AP:

A baby born with the virus that causes AIDS appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who’s now 2 1/2 and has been off medication for about a year with no signs of infection.

There’s no guarantee the child will remain healthy, although sophisticated testing uncovered just traces of the virus’ genetic material still lingering. If so, it would mark only the world’s second reported cure.

Specialists say Sunday’s announcement, at a major AIDS meeting in Atlanta, offers promising clues for efforts to eliminate HIV infection in children, especially in AIDS-plagued African countries where too many babies are born with the virus.

“You could call this about as close to a cure, if not a cure, that we’ve seen,” Dr. Anthony Fauci of the National Institutes of Health, who is familiar with the findings, told The Associated Press.

A doctor gave this baby faster and stronger treatment than is usual, starting a three-drug infusion within 30 hours of birth. That was before tests confirmed the infant was infected and not just at risk from a mother whose HIV wasn’t diagnosed until she was in labor.

“I just felt like this baby was at higher-than-normal risk, and deserved our best shot,” Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi, said in an interview.

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Remembering Fear: Andrew Sullivan on ‘How to Survive a Plague’

Ben Cohen · June 20,2012
Andrew Sullivan resized

Andrew Sullivan’s post about ‘How to Survive a Plague’, a new film on the gay civil rights movement and AIDS epidemic is an absolute must read. Key quote:

If you want to understand the gay civil rights movement in the last twenty years, you need to see this film. None of it would have happened as it did, if we had not been radicalized by mass death, stripped of fear by imminent death, and determined to bring meaning to the corpses of our loved ones by fighting for the basic rights every heterosexual has taken for granted since birth. No spouse was ever going to be turned away from his husband’s deathbed again, as far as I was concerned. Never. Again. For me, marriage equality is not an abstract concept. It has always been my attempt to make my friends’ deaths mean something more than tragedy. And it is non-negotiable.

Sullivan’s personal account of living through what he describes as a ‘mass sickness and death that killed five times as many young Americans as the Vietnam War in roughly the same period of time’ is a harrowing read in itself:

People forget that HIV decimated the immune system – but people actually died from the opportunistic infections. These “OI”s were something out of Dante’s Hell. So many drowned to death from pneumocystis. Or they would develop hideous KS lesions, or extremely painful neuropathy (my “buddy” screamed once when I brushed a bedsheet against the tip of his toes), or CMV where a friend of mine had to inject himself in the eyeball to prevent going blind, or toxoplasmosis, a brain degenerative disease where people wake up one day to find they can’t tie their shoe-laces, and their memories are falling apart. Within the gay community, 300,000 deaths amounted to a plague of medieval dimensions. Once you knew your T-cells were below a certain level, it was like being in a dark forest where, at any moment, some hideous viral or bacterial creature could emerge and kill you. And for fifteen years there was nothing to take that worked, just the agonizing helplessness of waiting to die, and watching others get assaulted by one terrifying disease after another.

That type of fear is unimaginable to most people – and to live with it for years defies the boundaries of human tolerance. It’s a topic I don’t know a huge deal about, but Sullivan’s post alone has given me even more respect for the gay community that not only fought to be treated as human beings, but suffered horrors akin to war – and for far, far longer.

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